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# Background: Understanding Non-Compartmental Analysis (NCA) and the Role of aNCA
This document will help you understand the fundamentals of Non-Compartmental Analysis (NCA) in pharmacokinetics (PK) and the challenges analysts face when performing NCA. It also explains why the aNCA application was developed and how it aims to streamline and enhance the NCA workflow. For a video-content referring to all these concepts you can also visit the [R Pharma aNCA video](https://www.youtube.com/watch?v=RW1zbnDkTCM).
This document will help you understand the fundamentals of Non-Compartmental Analysis (NCA) in pharmacokinetics (PK) and the challenges analysts face when performing NCA. It also explains why the aNCA application was developed and how it aims to streamline and enhance the NCA workflow.
~~This document will help you understand the fundamentals of Non-Compartmental Analysis (NCA) in pharmacokinetics (PK) and the challenges analysts face when performing NCA. It also explains why the aNCA application was developed and how it aims to streamline and enhance the NCA workflow.~~

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What you did will cross out the test, but what we want if it is repeated is probably to delete it

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~~This document will help you understand the fundamentals of Non-Compartmental Analysis (NCA) in pharmacokinetics (PK) and the challenges analysts face when performing NCA. It also explains why the aNCA application was developed and how it aims to streamline and enhance the NCA workflow.~~

@jimrothstein jimrothstein Apr 24, 2026

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@Gero1999

Strikeout

The sentence is a duplicate. The STRIKEOUT symbol is:

an old-fashioned way to propose changes to documents, before computers and CI/CD.

I will remove the strikeout from vignette.


As to the vignette itself:

First i want to outline my thinking and proposed changes in a separate document suggestions.md (will remove at very end). With suggestions.md, you can review my suggestions; add, discuss; etc.

If easier for you, I can keep the this document up-to-date. But appreciate if you comment, suggest additions, subtrations, etc. So consider suggestions.md a work-in-progress. If we go this way, it may take some to get it to our liking. But hopefully, make the actual changes to vignette easier.

Please see ../inst/suggestions.md (https://github.com/pharmaverse/aNCA/blob/1247_improve_text_What_is_NCA/inst/suggestions.md)


## What is Pharmacokinetics and Why Does NCA Matter?

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