Genetic variant analysis — on your desktop or self-hosted.
- Import annotated variant data from JSON files (single, batch, or ZIP)
- Filter by gene, consequence, population frequency, pathogenicity scores, and more
- Annotate variants with stars, comments, tags, and ACMG classifications
- Classify with ACMG criteria and auto-suggested evidence
- Analyze cohorts with carrier aggregation and gene burden testing
- Match phenotypes using HPO-based similarity scoring
- Export filtered results to Excel or CSV
- Store data locally in SQLite with optional encryption
For a complete walkthrough, see the feature documentation.
Download the latest release for your platform:
| Platform | Formats |
|---|---|
| Windows | Installer / Portable |
| macOS (Apple Silicon only) | DMG / ZIP |
| Linux | AppImage / DEB |
See the installation guide for system requirements and first-launch steps.
Requires Node.js 24.14.1+ and npm 11.11.0+. On Windows, also install Visual Studio Build Tools with the C++ workload.
npm install
make dev| Command | Description |
|---|---|
make dev |
Start development server with hot reload |
make lint |
Lint and auto-fix |
make typecheck |
TypeScript type checking |
make test |
Run unit tests |
make ci |
Lint + format check + typecheck + rebuild for Node + test |
make dist |
Build and package for current platform |
Vue 3 and Vuetify 4 (renderer), Electron 40 with electron-vite (build), SQLite via better-sqlite3-multiple-ciphers (storage), Pinia (state), Vitest and Playwright (testing), GitHub Actions (CI/CD).