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Question about the JGI metagenome dataset used for ESMC training

Status: Open.

#399 In Biohub/esm;

· kkbiu opened on Sep 5, 2026

Request to release the designed binder sequences and assay results.

Status: Open.

#396 In Biohub/esm;

· JudeWells opened on Sep 3, 2026

Structure prediction with residue level restraints

Status: Open.

#336 In Biohub/esm;

· KejserMikael1 opened on Jun 4, 2026

Recommended way to assess binding affinities for mAb-antigen predictions?

Status: Open.

#330 In Biohub/esm;

· avilella opened on Jun 2, 2026

Unable to access models through EvolutionaryScale Forge:

Status: Open.

#296 In Biohub/esm;

· cgseitz opened on Jan 20, 2026

Performance discrepancy with nan coordinates vs coordinates=None

Status: Open.

#294 In Biohub/esm;

· jsjung00 opened on Dec 19, 2025

Protein generation around active site without specifying residue numbers

Status: Open.

#288 In Biohub/esm;

· Xuebin-Feng opened on Nov 8, 2025

ESMProtein.from_pdb() ignores HETATOM

Status: Open.

#287 In Biohub/esm;

· Ento0n opened on Nov 5, 2025

Validate ESM3-VQVAE Scripts

Status: Open.

#277 In Biohub/esm;

· mahdip72 opened on Oct 3, 2025

How to enable batch training?

Status: Open.

#260 In Biohub/esm;

· yuliangyan0807 opened on Jul 30, 2025

Missing contact-regression model file for esmc_600m_2024_12_v0

Status: Open.

#259 In Biohub/esm;

· aowuawu opened on Jul 23, 2025

ESM models fail on CPU when flash_attn is installed

Status: Open.

#242 In Biohub/esm;

· karinazad opened on May 21, 2025