diff --git a/src/bindings/crypto_onetimeauth.h b/src/bindings/crypto_onetimeauth.h
new file mode 100644
index 00000000..224a7e4e
--- /dev/null
+++ b/src/bindings/crypto_onetimeauth.h
@@ -0,0 +1,12 @@
+int crypto_onetimeauth(unsigned char *out,
+                       const unsigned char *in,
+                       unsigned long long inlen,
+                       const unsigned char *k);
+
+int crypto_onetimeauth_verify(const unsigned char *h,
+                              const unsigned char *in,
+                              unsigned long long inlen,
+                              const unsigned char *k);
+
+size_t crypto_onetimeauth_bytes(void);
+size_t crypto_onetimeauth_keybytes(void);
diff --git a/src/nacl/bindings/__init__.py b/src/nacl/bindings/__init__.py
index 2e07ba1e..83d8d023 100644
--- a/src/nacl/bindings/__init__.py
+++ b/src/nacl/bindings/__init__.py
@@ -130,6 +130,12 @@
     crypto_kx_seed_keypair,
     crypto_kx_server_session_keys,
 )
+from nacl.bindings.crypto_onetimeauth import (
+    crypto_onetimeauth,
+    crypto_onetimeauth_verify,
+    crypto_onetimeauth_BYTES,
+    crypto_onetimeauth_KEYBYTES,
+)
 from nacl.bindings.crypto_pwhash import (
     crypto_pwhash_ALG_ARGON2I13,
     crypto_pwhash_ALG_ARGON2ID13,
@@ -378,6 +384,10 @@
     "crypto_kx_SECRET_KEY_BYTES",
     "crypto_kx_SEED_BYTES",
     "crypto_kx_SESSION_KEY_BYTES",
+    "crypto_onetimeauth",
+    "crypto_onetimeauth_verify",
+    "crypto_onetimeauth_BYTES",
+    "crypto_onetimeauth_KEYBYTES",
     "has_crypto_scalarmult_ed25519",
     "crypto_scalarmult_BYTES",
     "crypto_scalarmult_SCALARBYTES",
diff --git a/src/nacl/bindings/crypto_onetimeauth.py b/src/nacl/bindings/crypto_onetimeauth.py
new file mode 100644
index 00000000..b5eec6b2
--- /dev/null
+++ b/src/nacl/bindings/crypto_onetimeauth.py
@@ -0,0 +1,39 @@
+from nacl._sodium import ffi, lib
+
+
+crypto_onetimeauth_BYTES = lib.crypto_onetimeauth_bytes()
+crypto_onetimeauth_KEYBYTES = lib.crypto_onetimeauth_keybytes()
+
+
+def crypto_onetimeauth(message: bytes, key: bytes) -> bytes:
+    """
+    Generate Poly1305 MAC over message with key.
+
+    :param message: data to authenticate
+    :param key: 32-bytes Poly1305 key
+    :return: 16-bytes MAC (tag)
+    """
+    if len(key) != crypto_onetimeauth_KEYBYTES:
+        raise ValueError(f"Key must be {crypto_onetimeauth_KEYBYTES} bytes")
+
+    mac = ffi.new(f"unsigned char[{crypto_onetimeauth_BYTES}]")
+    lib.crypto_onetimeauth(mac, message, len(message), key)
+    return ffi.buffer(mac, crypto_onetimeauth_BYTES)[:]
+
+
+def crypto_onetimeauth_verify(mac: bytes, message: bytes, key: bytes) -> bool:
+    """
+    Verify if mac is valid for message and key.
+
+    :param mac: 16-bytes MAC/tag to check
+    :param message: data
+    :param key: 32-bytes key
+    :return: True on valid MAC, else False
+    """
+    if len(mac) != crypto_onetimeauth_BYTES:
+        raise ValueError(f"MAC must be {crypto_onetimeauth_BYTES} bytes")
+    if len(key) != crypto_onetimeauth_KEYBYTES:
+        raise ValueError(f"Key must be {crypto_onetimeauth_KEYBYTES} bytes")
+
+    rc = lib.crypto_onetimeauth_verify(mac, message, len(message), key)
+    return rc == 0
diff --git a/tests/test_bindings.py b/tests/test_bindings.py
index a89c361c..61069016 100644
--- a/tests/test_bindings.py
+++ b/tests/test_bindings.py
@@ -1020,3 +1020,30 @@ def test_scalarmult_ed25519_unavailable():
         c.crypto_scalarmult_ed25519(zero, zero)
     with pytest.raises(UnavailableError):
         c.crypto_scalarmult_ed25519_noclamp(zero, zero)
+
+
+def test_onetimeauth_wrong_length():
+    with pytest.raises(ValueError):
+        c.crypto_onetimeauth(b"", b"")
+    with pytest.raises(ValueError):
+        c.crypto_onetimeauth(b"message", b"")
+    with pytest.raises(ValueError):
+        c.crypto_onetimeauth_verify(b"", b"", b"")
+    with pytest.raises(ValueError):
+        c.crypto_onetimeauth_verify(
+            b"\x00" * c.crypto_onetimeauth_BYTES, b"message", b""
+        )
+    with pytest.raises(ValueError):
+        c.crypto_onetimeauth_verify(
+            b"", b"message", b"\x00" * c.crypto_onetimeauth_KEYBYTES
+        )
+
+
+def test_onetimeauth():
+    key = b"\x01" * c.crypto_onetimeauth_KEYBYTES
+    msg = b"message"
+
+    mac = c.crypto_onetimeauth(msg, key)
+    assert tohex(mac) == "4cee137430de76761b1d11751b1d1175"
+
+    assert c.crypto_onetimeauth_verify(mac, msg, key)