diff --git a/.github/workflows/jupyterlite.yml b/.github/workflows/jupyterlite.yml
new file mode 100644
index 00000000000..c06af5601ae
--- /dev/null
+++ b/.github/workflows/jupyterlite.yml
@@ -0,0 +1,46 @@
+name: Build JupyterLite
+
+on:  # yamllint disable-line rule:truthy
+  push:
+    branches:
+      - jupyterlite-gh-actions
+
+permissions:
+  contents: read
+
+jobs:
+  build:
+    name: Build JupyterLite Site
+    runs-on: ubuntu-latest
+    steps:
+      - name: Checkout repository
+        uses: actions/checkout@v4
+        with:
+          persist-credentials: false
+
+      - name: Setup Python
+        uses: actions/setup-python@v5
+        with:
+          python-version: '3.11'
+
+      - name: Install JupyterLite & Build Tools
+        run: |
+          python -m pip install --upgrade pip
+          pip install jupyterlite-core jupyterlite-pyodide-kernel build jupyter-server
+
+      - name: Build MNE-Python Wheel
+        run: |
+          python -m build --wheel
+          mkdir -p lite-wheels
+          cp dist/*.whl lite-wheels/
+
+      - name: Build JupyterLite Site
+        # We pass the local wheel to JupyterLite so the browser environment uses the exact code from this branch!
+        run: |
+          jupyter lite build --contents examples/ --output-dir dist_lite/ --piplite-wheel lite-wheels/*.whl
+
+      - name: Upload Artifact
+        uses: actions/upload-artifact@v4
+        with:
+          name: jupyterlite-build
+          path: dist_lite/
diff --git a/doc/changes/dev/13925.newfeature.rst b/doc/changes/dev/13925.newfeature.rst
new file mode 100644
index 00000000000..bcd3109e8d1
--- /dev/null
+++ b/doc/changes/dev/13925.newfeature.rst
@@ -0,0 +1 @@
+Added a JupyterLite GitHub Actions workflow to automatically build a Wasm-compatible interactive documentation site by Natneal Belete.
diff --git a/doc/conf.py b/doc/conf.py
index f14026d21c6..93d7742e970 100644
--- a/doc/conf.py
+++ b/doc/conf.py
@@ -113,6 +113,7 @@
     # contrib
     "matplotlib.sphinxext.plot_directive",
     "numpydoc",
+    "jupyterlite_sphinx",
     "sphinx_copybutton",
     "sphinx_design",
     "sphinx_gallery.gen_gallery",
@@ -473,6 +474,29 @@
 
 sphinx_gallery_parallel = int(os.getenv("MNE_DOC_BUILD_N_JOBS", "1"))
 sphinx_gallery_conf = {
+    "jupyterlite": {
+        "use_jupyter_lab": True,
+    },
+    "first_notebook_cell": (
+        "# 💡 This cell is automatically added to the start of each notebook.\n"
+        "import micropip\n"
+        "await micropip.install(['mne', 'pyodide-http'])\n"
+        "\n"
+        "# 1. Patch networking so pooch can download datasets\n"
+        "import pyodide_http\n"
+        "pyodide_http.patch_all()\n"
+        "\n"
+        "# 2. Patch MNEBrowseFigure to auto-display in Pyodide's inline backend\n"
+        "import mne\n"
+        "import mne.viz.utils\n"
+        "import matplotlib.pyplot as plt\n"
+        "orig_plt_show = mne.viz.utils.plt_show\n"
+        "def pyodide_plt_show(fig=None, **kwargs):\n"
+        "    orig_plt_show(fig, **kwargs)\n"
+        "    import IPython.display\n"
+        "    IPython.display.display(plt.gcf())\n"
+        "mne.viz.utils.plt_show = pyodide_plt_show\n"
+    ),
     "doc_module": ("mne",),
     "reference_url": dict(mne=None),
     "examples_dirs": examples_dirs,
diff --git a/pyproject.toml b/pyproject.toml
index c4a5a3cf13e..653a23ef616 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -9,6 +9,8 @@ doc = [
   "graphviz",
   "intersphinx_registry >= 0.2405.27",
   "ipython != 8.7.0",  # also in "full-no-qt" and "test"
+  "jupyterlite-pyodide-kernel",
+  "jupyterlite-sphinx",
   "memory_profiler >= 0.16",
   "mne-bids",
   "mne-connectivity",