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No. A variant that falls outside every feature in your annotation is still
reported, as a row of its own:

Column What it says
Gene intergenic
AA Changes -
SO Term intergenic_variant
Impact MODIFIER

So an intergenic variant is an answer, not a silence. The amino acid column is
- because there is no codon to translate, not because something went wrong.

If you would rather not see them, --exclude-intergenic removes them.

Worth knowing separately: a variant inside a gene can also come back with -
in the amino acid column, when no codon can be built for it. That is also a
reported row, not a dropped one.

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Paururo
Aug 16, 2026
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