diff --git a/python3/README.md b/python3/README.md
index 181f688c2..6cf38598d 100644
--- a/python3/README.md
+++ b/python3/README.md
@@ -17,6 +17,62 @@ On debian13+ we include a pre-generated `ld.so.cache` to support user/framework
 
 ## Usage
 
-The entrypoint of this image is set to "python", so this image expects users to supply a path to a .py file in the CMD.
+This image is intended to run Python applications directly.
 
 See the Python [Hello World](../examples/python3/) directory for an example.
+
+---
+
+## ⚠️ Important Usage Notes
+
+### Python Version Compatibility
+
+The Python version included in distroless images is provided by the underlying
+Debian distribution. Users must ensure that any Python packages copied into the
+image were built using the **exact same Python minor version**.
+
+❌ Unsupported / unsafe pattern
+
+- Installing dependencies using Python 3.12 in a builder stage
+- Copying `/usr/local/lib/python3.12` or site-packages into a distroless image
+  that uses Python 3.11
+
+This may result in runtime errors such as:
+
+- `SyntaxError: Non-UTF-8 code starting with '\x80'`
+- `No module named <package>`
+- Segmentation faults or crashes at startup
+
+These failures are caused by ABI incompatibilities between Python versions.
+
+---
+
+### Recommended Usage
+
+Distroless Python images are best suited for:
+
+- Pure-Python applications
+- Minimal dependencies
+- Environments where Python version alignment is guaranteed
+
+For applications with native extensions (e.g. numpy, pandas, torch, ML workloads),
+consider using `python:<version>-slim` images instead.
+
+---
+
+### Execution Model
+
+### Execution Model
+
+Distroless images do not include a shell.
+
+The `python3` image provides a default ENTRYPOINT that invokes the Python
+interpreter, which allows users to supply a script directly via `CMD`
+(as demonstrated in the `examples/python3` directory).
+
+However, for maximum clarity and to avoid ambiguity—especially in more complex
+container configurations—it is often preferable to explicitly invoke the
+interpreter using an absolute path:
+
+```dockerfile
+CMD ["/usr/bin/python3", "-m", "your_module"]